Comparative Study of the Effects of Tetraethyl-
نویسندگان
چکیده
Persistence of elevated blood pressure in toxemia of pregnancy following autonomic blockade with tetraethylammonium chloride (TEAC) has been reported previously by the authors ( 1 ). Subsequently many of the patients studied were treated with subcutaneous veratrum viride with consistent depressor effects. The apparent opposing actions of these two drugs in toxemia, together with a suggestion that one tends to negate the effect of the other, have served as the stimulus for the present study. In an effort to obtain suggestions as to the site and mechanism of action of veratrum, it was decided to compare blood pressure responses to both veratrum and TEAC intravenously in the same patients. The latter drug, an autonomic blocking agent, has been demonstrated to produce diametrically opposite blood pressure effects in normal pregnancy and toxemia (1). In toxemic pregnancies, TEAC invoked negligible blood pressure responses with persistence of diastolic hypertension, whereas in normal pregnancies the same drug invariably produced a fall in the diastolic blood pressure to levels of 50-60 mm. Hg. These results were interpreted as indicating a predominance of humoral tone in toxemic hypertension as opposed to a predominance of neurogenic tone in normal pregnancy at term. Thus, this comparative study of blood pressure responses of toxemic and normal pregnant patients was undertaken in an effort to quantitate the depressor effect of veratrum, to seek clues as to its pharmacologic action, and to correlate further the humoral and neurogenic interrelationships postulated by previous studies.
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